Clark, KE;
Giles, I;
(2022)
Updates on the antiphospholipid syndrome.
Medicine
, 50
(1)
pp. 47-54.
10.1016/j.mpmed.2021.10.008.
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Abstract
Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia characterized by venous or arterial thrombosis, and/or pregnancy loss or complications in the presence of persistently positive antiphospholipid antibodies. Organ involvement, referred to as non-criteria manifestations, includes livedo reticularis, thrombocytopenia and nephropathy. Non-thrombotic inflammatory mechanisms are increasingly identified in the pathogenesis of APS, alongside a recognition that obstetric APS might be a specific subset of APS. Treatment remains focused on life-long anticoagulation and prevention of further thrombosis or obstetric complications. Identification of novel mechanisms is, however, leading the development of diagnostic tests and more targeted therapies to improve disease management.
| Type: | Article |
|---|---|
| Title: | Updates on the antiphospholipid syndrome |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mpmed.2021.10.008 |
| Publisher version: | https://doi.org/10.1016/j.mpmed.2021.10.008 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | β2-glycoprotein-1 antibodies; anticardiolipin antibodies; anticoagulation; antiphospholipid syndrome; complement; lupus anticoagulant; MRCP; obstetric morbidity; thrombosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10140944 |
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