Awad, A;
Madla, CM;
McCoubrey, LE;
Ferraro, F;
Gavins, FKH;
Buanz, A;
Gaisford, S;
... Basit, AW; + view all
(2022)
Clinical translation of advanced colonic drug delivery technologies.
Advanced Drug Delivery Reviews
, 181
, Article 114076. 10.1016/j.addr.2021.114076.
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Abstract
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are available, these systems exhibit inconsistent drug release due to physiological variability between and within individuals, which may be further exacerbated by underlying disease states. In recent years, significant translational and commercial advances have been made with the introduction of new technologies that incorporate multi-stimuli independent release mechanisms (pH or microbiota-dependent release). Harnessing these advanced technologies offers new possibilities for drug delivery via the colon, including the delivery of biopharmaceuticals, vaccines, nutrients, and microbiome therapeutics for treatment of both local and systemic diseases. This review details the latest advances in colonic drug delivery with an emphasis on emerging therapeutic opportunities and clinical technology translation.
| Type: | Article |
|---|---|
| Title: | Clinical translation of advanced colonic drug delivery technologies |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.addr.2021.114076 |
| Publisher version: | https://doi.org/10.1016/j.addr.2021.114076 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 3D printing drug products, ASACOL 1600, Chronotherapy, Colonic drug targeting, Drug delivery to the large intestine, Mesalazine, OPTICORE, Phloral, Resistant starch film coatings, Ulcerative colitis and Crohn’s disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10140549 |
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