Torii, R;
Yacoub, MH;
(2021)
CT-based fractional flow reserve: development and expanded application.
Global Cardiology Science & Practice
, 2021
(3)
, Article e202120. 10.21542/gcsp.2021.20.
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Abstract
Computations of fractional flow reserve, based on CT coronary angiography and computational fluid dynamics (CT-based FFR) to assess the severity of coronary artery stenosis, was introduced around a decade ago and is now one of the most successful applications of computational fluid dynamic modelling in clinical practice. Although the mathematical modelling framework behind this approach and the clinical operational model vary, its clinical efficacy has been demonstrated well in general. In this review, technical elements behind CT-based FFR computation are summarised with some key assumptions and challenges. Examples of these challenges include the complexity of the model (such as blood viscosity and vessel wall compliance modelling), whose impact has been debated in the research. Efforts made to address the practical challenge of processing time are also reviewed. Then, further application areas – myocardial bridge, renal stenosis and lower limb stenosis – are discussed along with specific challenges expected in these areas.
| Type: | Article |
|---|---|
| Title: | CT-based fractional flow reserve: development and expanded application |
| Location: | Qatar |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.21542/gcsp.2021.20 |
| Publisher version: | https://doi.org/10.21542/gcsp.2021.20 |
| Language: | English |
| Additional information: | Copyright © 2021 Ryo Torii, Magdi H Yacoub. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10139497 |
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