Slonina, ZA;
Poole, KC;
Bizley, JK;
(2021)
What can we learn from inactivation studies? Lessons from auditory cortex.
Trends in Neurosciences
10.1016/j.tins.2021.10.005.
(In press).
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Abstract
Wide variation in the outcome of auditory cortex inactivation has been an impediment to clear conclusions regarding the roles of the auditory cortex in behaviour. Inactivation methods differ in their efficacy and specificity. The likelihood of observing a behavioural deficit is additionally influenced by factors such as the species being used, task design and reward. A synthesis of previous results suggests that auditory cortex involvement is critical for tasks that require integrating across multiple stimulus features, and less likely to be critical for simple feature discriminations. New methods of neural silencing provide opportunities for spatially and temporally precise manipulation of activity, allowing perturbation of individual subfields and specific circuits.
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