Bohrer, AC;
Castro, E;
Hu, Z;
Queiroz, ATL;
Tocheny, CE;
Assmann, M;
Sakai, S;
... Mayer-Barber, KD; + view all
(2021)
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice.
Journal of Experimental Medicine
, 218
(10)
, Article e20210469. 10.1084/jem.20210469.
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Abstract
Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.
| Type: | Article |
|---|---|
| Title: | Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1084/jem.20210469 |
| Publisher version: | https://doi.org/10.1084/jem.20210469 |
| Language: | English |
| Additional information: | This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| Keywords: | Infectious disease and host defense, Innate immunity and inflammation, Mucosal immunology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10138753 |
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