Spears, RJ;
McMahon, C;
Shamsabadi, M;
Bahou, C;
Thanasi, IA;
Rochet, LNC;
Forte, N;
... Chudasama, V; + view all
(2021)
A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold.
Chemical Communications
10.1039/d1cc03802h.
(In press).
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Abstract
Herein we report a thiol-labile cysteine protecting group based on an unsaturated pyridazinedione (PD) scaffold. We establish compatibility of the PD in conventional solid phase peptide synthesis (SPPS), showcasing this in the on-resin synthesis of biologically relevant oxytocin. Furthermore, we establish the applicability of the PD protecting group towards both microwave-assisted SPPS and native chemical ligation (NCL) in a model system.
| Type: | Article |
|---|---|
| Title: | A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d1cc03802h |
| Publisher version: | https://doi.org/10.1039/d1cc03802h |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, DISULFIDE FORMATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10138702 |
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