Arshad, Mayda;
(2021)
Modified Dental Composites for Bone Repair.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
The aim of this project was to develop modified dental composites for bone repair with additional remineralising monocalcium phosphate monohydrate (MCPM) and antibacterial polylysine (PLS). Bone composites were prepared with the powder to monomer weight ratio of 3:1. The monomer phase consisted of dimethacrylate monomers with chemical curing initiator and activator. Powder phase consisted of glass filler, PLS as antibacterial agent and MCPM as the mineralising agent. The level of remineralising agent and PLS were varied amongst formulations. Commercial polymethylmethacrylate (PMMA) (SimplexTM P) and bone composite (Cortoss®) were used for comparison. Degree of monomer conversion (DC) was assessed using fourier transform infrared spectroscopy (FTIR) (n=3). Biaxial flexural strength (BFS), tested by means of ball on ring technique, was used to compare the mechanical properties of each formulation (n=6). Surface apatite forming ability was carried out using scanning electron microscopy (SEM). Toxicity of monomers were assessed with sheep mesenchymal stem cells (MSCs) and MG63 cells using an Alamar Blue assay. Chick Embryo Chorioallantoic Membrane (CAM) assay was carried out to assess angiogenesis and development of a chick embryo upon contact with the experimental bone composite.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Modified Dental Composites for Bone Repair |
| Event: | UCL (University College London) |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2021. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10138536 |
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