Majumdar, A;
Verbeek, J;
Tsochatzis, EA;
(2021)
Non-alcoholic fatty liver disease: Current therapeutic options.
Current Opinion in Pharmacology
, 61
pp. 98-105.
10.1016/j.coph.2021.09.007.
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Abstract
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated global prevalence of 25%. NAFLD is found in up to 80% of people with obesity and over 60% of patients with diabetes. Cardiovascular disease is the main cause of mortality, followed by extra-hepatic cancers and then liver-specific complications of cirrhosis and hepatocellular carcinoma. Lifestyle modification remains the primary intervention in NAFLD. Weight loss achieved through dietary modification and exercise can lead to histologic improvement and reversal of metabolic complications. Current drug therapy is limited to pioglitazone and vitamin E; however, several agents are currently under phase III development. This review summarises the current treatment options in NAFLD.
| Type: | Article |
|---|---|
| Title: | Non-alcoholic fatty liver disease: Current therapeutic options |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.coph.2021.09.007 |
| Publisher version: | https://doi.org/10.1016/j.coph.2021.09.007 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10138479 |
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