Lin, W-Y;
Fordham, SE;
Hungate, E;
Sunter, NJ;
Elstob, C;
Xu, Y;
Park, C;
... Allan, JM; + view all
(2021)
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Nature Communications
, 12
(1)
, Article 6233. 10.1038/s41467-021-26551-x.
Preview |
Text
Gale_Genome-wide association study identifies susceptibility loci for acute myeloid leukemia_VoR.pdf - Published Version Download (25MB) | Preview |
Abstract
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10^{-8}; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10^{−10}; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
Archive Staff Only
 |
View Item |
