Rotta, J;
Perosa, V;
Yakupov, R;
Kuijf, HJ;
Schreiber, F;
Dobisch, L;
Oltmer, J;
... Schreiber, S; + view all
(2021)
Detection of Cerebral Microbleeds With Venous Connection at 7-Tesla MRI.
Neurology
, 96
(16)
E2048-E2057.
10.1212/WNL.0000000000011790.
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Rotta Revision_Detection of cerebral microbleeds with venous connection at 7 Tesla MRI_19112020.pdf - Accepted Version Download (349kB) | Preview |
Abstract
Objective: Cerebral microbleeds (MBs) are a common finding in patients with cerebral small vessel disease (CSVD) and Alzheimer disease as well as in healthy elderly people, but their pathophysiology remains unclear. To investigate a possible role of veins in the development of MBs, we performed an exploratory study, assessing in vivo presence of MBs with a direct connection to a vein. Methods: 7-Tesla (7T) MRI was conducted and MBs were counted on quantitative susceptibility mapping (QSM). A submillimeter resolution QSM-based venogram allowed identification of MBs with a direct spatial connection to a vein. Results: A total of 51 people (mean age [SD] 70.5 [8.6] years, 37% female) participated in the study: 20 had CSVD (cerebral amyloid angiopathy [CAA] with strictly lobar MBs [n = 8], hypertensive arteriopathy [HA] with strictly deep MBs [n = 5], or mixed lobar and deep MBs [n = 7], 72.4 [6.1] years, 30% female) and 31 were healthy controls (69.4 [9.9] years, 42% female). In our cohort, we counted a total of 96 MBs with a venous connection, representing 14% of all detected MBs on 7T QSM. Most venous MBs (86%, n = 83) were observed in lobar locations and all of these were cortical. Patients with CAA showed the highest ratio of venous to total MBs (19%) (HA = 9%, mixed = 18%, controls = 5%). Conclusion: Our findings establish a link between cerebral MBs and the venous vasculature, pointing towards a possible contribution of veins to CSVD in general and to CAA in particular. Pathologic studies are needed to confirm our observations.
| Type: | Article |
|---|---|
| Title: | Detection of Cerebral Microbleeds With Venous Connection at 7-Tesla MRI |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1212/WNL.0000000000011790 |
| Publisher version: | https://doi.org/10.1212/WNL.0000000000011790 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Clinical Neurology, Neurosciences & Neurology, WHITE-MATTER HYPERINTENSITIES, DEEP MEDULLARY VEINS, SMALL VESSEL DISEASE, AMYLOID ANGIOPATHY, PREVALENCE, HEMORRHAGE, DEMENTIA, IMAGES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10138383 |
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