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Drosophila as a Model for Hearing and Deafness

Albert, J; Jarman, A; Kamikouchi, A; Keder, A; (2020) Drosophila as a Model for Hearing and Deafness. In: Fritzsch, B, (ed.) The Senses: A Comprehensive Reference. (pp. 985-1004). Elsevier Green open access

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Abstract

As evidenced not least by its age-related breakdown in humans, hearing is a delicate physiological process. Across the animal kingdom, ears operate at the borders of the physically, and the biologically, possible. Human biomedical need, evolutionary convergence, as well as mechanistic similarities are strong arguments for exploiting the scientific power of the fruit fly Drosophila melanogaster to understand hearing - and ultimately fight deafness. This chapter provides an overview of the fly's auditory system and highlights the various ways by which Drosophila studies can inform, and advance, human hearing research.

Type: Book chapter
Title: Drosophila as a Model for Hearing and Deafness
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/B978-0-12-809324-5.24216-8
Publisher version: https://doi.org/10.1016/B978-0-12-809324-5.24216-8
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Age-related hearing loss (ARHL); Antennal hearing; Auditory homeostasis; Auditory transduction; Chordotonal organ; Congenital hearing loss; Ciliogenesis; Deafness; Diptera; Drosophila model; Hearing loss; Johnston's organ; Noise-induced hearing loss (NIHL); Scolopidia; Sound processing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10137853
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