Ney, A;
Garcia-Sampedro, A;
Goodchild, G;
Acedo, P;
Fusai, G;
Pereira, SP;
(2021)
Biliary Strictures and Cholangiocarcinoma - Untangling a Diagnostic Conundrum.
Frontiers in Oncology
, 11
, Article 699401. 10.3389/fonc.2021.699401.
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Abstract
Cholangiocarcinoma is an uncommon and highly aggressive biliary tract malignancy with few manifestations until late disease stages. Diagnosis is currently achieved through a combination of clinical, biochemical, radiological and histological techniques. A number of reported cancer biomarkers have the potential to be incorporated into diagnostic pathways, but all lack sufficient sensitivity and specificity limiting their possible use in screening and early diagnosis. The limitations of standard serum markers such as CA19-9, CA125 and CEA have driven researchers to identify multiple novel biomarkers, yet their clinical translation has been slow with a general requirement for further validation in larger patient cohorts. We review recent advances in the diagnostic pathway for suspected CCA as well as emerging diagnostic biomarkers for early detection, with a particular focus on non-invasive approaches.
| Type: | Article |
|---|---|
| Title: | Biliary Strictures and Cholangiocarcinoma - Untangling a Diagnostic Conundrum |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fonc.2021.699401 |
| Publisher version: | https://doi.org/10.3389/fonc.2021.699401 |
| Language: | English |
| Additional information: | © 2021 Ney, Garcia-Sampedro, Goodchild, Acedo, Fusai and Pereira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | ERCP (Endoscopic Retrograde Cholangiopancreatography), biliary strictures, biomarkers, cholangiocarcinoma, early detection, primary sclerosing cholangitis (PSC) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10137139 |
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