Berks, M;
Parker, G;
Little, R;
Cheung, S;
(2021)
Madym: A C++ toolkit for quantitative DCE-MRI analysis.
Journal of Open Source Software
, 6
(66)
, Article 3523. 10.21105/joss.03523.
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Abstract
In dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) a sequence of MRI images are acquired to measure the passage of a contrast-agent within a tissue of interest. Quantitative DCE-MRI (DCE-MRI), in which one or more tracer-kinetic models are fitted to the contrast-agent concentration time-series, enables the estimation of clinically useful parameters of tissue microvasculature (Tofts et al., 1999). Madym is a C++ toolkit for quantitative DCE-MRI analysis developed at the University of Manchester. It comprises a set of command line tools and a graphical user-interface based on an extendable C++ library. It is cross-platform, and requires few external libraries to build from source. Pre-built binaries (with all dependencies included) for Windows, MacOS and Linux are available so that Madym can be installed directly for users not wanting to or unable to compile the C++ source themselves. We have also developed complementary interfaces in Matlab (available in a separate open-source repository (M. Berks, 2021b)) and python (integrated with the main toolkit), that allow the flexibility of developing in those scripting languages, while allowing C++ to do the heavy-duty computational work of tracer-kinetic model fitting
| Type: | Article |
|---|---|
| Title: | Madym: A C++ toolkit for quantitative DCE-MRI analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.21105/joss.03523 |
| Publisher version: | https://doi.org/10.21105/joss.03523 |
| Language: | English |
| Additional information: | Authors of JOSS papers retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10136419 |
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