Maeurer, M;
Ramalho, R;
Wang, F-S;
Zumla, A;
(2021)
Host-directed therapies for COVID-19.
Current Opinion in Pulmonary Medicine
, 27
(3)
pp. 205-209.
10.1097/MCP.0000000000000769.
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Zumla_HDT for COVID-19 Final version- COPM Maeurer, et al 26.01.2021 HDT for COVID-19.pdf - Accepted Version Download (235kB) | Preview |
Abstract
Purpose of review: Severe acute respiratory syndrome coronavirus-2-induced hyperinflammation is a major cause of death or end-organ dysfunction in COVID-19 patients. We review adjunct host-directed therapies (HDTs) for COVID-19 management. Recent findings: The use of umbilical cord-derived mesenchymal stem cells as HDT for COVID-19 has been shown to be safe in phase 1 and 2 trials. Trials of anti-interleukin-6 receptor antibodies show promising mortality benefit in hospitalized COVID-19 patients. Repurposed drugs and monoclonal antibodies targeting specific cytokines acting on different aspects of the pro- and anti-inflammatory cascades are under evaluation. Summary: A range of HDTs shows promise for reducing mortality and improving long term disability in patients with severe COVID-19, and require evaluation in randomized, controlled trials
| Type: | Article |
|---|---|
| Title: | Host-directed therapies for COVID-19 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/MCP.0000000000000769 |
| Publisher version: | http://dx.doi.org/10.1097/MCP.0000000000000769 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Respiratory System, COVID-19, host-directed therapies, interleukins, mesenchymal stem cells, severe acute respiratory syndrome coronavirus-2, REDUCING MORTALITY, DISEASE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10136368 |
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