Powell, E;
Battocchio, M;
Parker, CS;
Slator, PJ;
(2021)
Generalised Hierarchical Bayesian Microstructure Modelling for Diffusion MRI.
In: Cetin-Karayumak, S and Christiaens, D and Figini, M and Guevara, P and Gyori, N and Nath, V and Pieciak, T, (eds.)
Computational Diffusion MRI: 12th International Workshop, CDMRI 2021, Held in Conjunction with MICCAI 2021, Strasbourg, France, October 1, 2021, Proceedings.
(pp. pp. 36-47).
Springer: Cham, Switzerland.
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Abstract
Microstructure imaging combines tailored diffusion MRI acquisition protocols with a mathematical model to give insights into subvoxel tissue features. The model is typically fit voxel-by-voxel to the MRI image with least squares minimisation to give voxelwise maps of parameters relating to microstructural features, such as diffusivities and tissue compartment fractions. However, this fitting approach is susceptible to voxelwise noise, which can lead to erroneous values in parameter maps. Data-driven Bayesian hierarchical modelling defines prior distributions on parameters and learns them from the data, and can hence reduce such noise effects. Bayesian hierarchical modelling has been demonstrated for microstructure imaging with diffusion MRI, but only for a few, relatively simple, models. In this paper, we generalise hierarchical Bayesian modelling to a wide range of multi-compartment microstructural models, and fit the models with a Markov chain Monte Carlo (MCMC) algorithm. We implement our method by utilising Dmipy, a microstructure modelling software package for diffusion MRI data. Our code is available at github.com/PaddySlator/dmipy-bayesian.
| Type: | Proceedings paper |
|---|---|
| Title: | Generalised Hierarchical Bayesian Microstructure Modelling for Diffusion MRI |
| Event: | 12th International Workshop, CDMRI 2021 |
| ISBN-13: | 978-3-030-87614-2 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-030-87615-9_4 |
| Publisher version: | https://doi.org/10.1007/978-3-030-87615-9_4 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Bayesian statistics, Bayesian hierarchical model, Microstructure modelling, Diffusion MRI |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10135780 |
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