Zheng, F;
Li, Y;
Zhuo, Z;
Duan, Y;
Cao, G;
Tian, D;
Zhang, X;
... Liu, Y; + view all
(2021)
Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder.
Multiple Sclerosis Journal
10.1177/13524585211032800.
(In press).
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Barkhof_Zheng - Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder - MSJ-R3-manuscript 2-yl-new.pdf - Accepted Version Download (276kB) | Preview |
Abstract
Background: Hippocampal involvement may differ between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Objective: To investigate the morphometric, diffusion and functional alterations in hippocampus in MS and NMOSD and the clinical significance. Methods: A total of 752 participants including 236 MS, 236 NMOSD and 280 healthy controls (HC) were included in this retrospective multi-center study. The hippocampus and subfield volumes, fractional anisotropy (FA) and mean diffusivity (MD), amplitude of low frequency fluctuation (ALFF) and degree centrality (DC) were analyzed, and their associations with clinical variables were investigated. Results: The hippocampus showed significantly lower volume, FA and greater MD in MS compared to NMOSD and HC (p < 0.05), while no abnormal ALFF or DC was identified in any group. Hippocampal subfields were affected in both diseases, though subiculum, presubiculum and fimbria showed significantly lower volume only in MS (p < 0.05). Significant correlations between diffusion alterations, several subfield volumes and clinical variables were observed in both diseases, especially in MS (R = −0.444 to 0.498, p < 0.05). FA and MD showed fair discriminative power between MS and HC, NMOSD and HC (AUC > 0.7). Conclusions: Hippocampal atrophy and diffusion abnormalities were identified in MS and NMOSD, partly explaining how clinical disability and cognitive impairment are differentially affected.
| Type: | Article |
|---|---|
| Title: | Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/13524585211032800 |
| Publisher version: | https://doi.org/10.1177/13524585211032800 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Assessment of cognitive, Multiple sclerosis, MRI, Neuromyelitis optica spectrum disorder, Hippocampus, Hippocampal subfields, ATROPHY, MEMORY, DISABILITY, VIVO, MS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10135538 |
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