Jiang, K;
Slee, A;
Davenport, A;
(2021)
Screening Tests for Sarcopenia in Patients with Chronic Kidney Disease.
Nutrition in Clinical Practice
, 36
(5)
pp. 1049-1052.
10.1002/ncp.10597.
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Abstract
Background: Patients with chronic kidney disease (CKD) are at increased risk of muscle wasting. Screening tools for sarcopenia, including the Sarc-F questionnaire are now advocated for clinical practice. We wished to compare using the Sarc-F tool with standard measurements of hand grip (HGS) strength and appendicular muscle mass index (APMI). Methods: We retrospectively reviewed Sarc-F questionnaires completed by patients with CKD, along with contemporaneous measurements of HGS and bioimpedance measured APMI. Results: 146 patients; 94 male (64.4%), mean age 70.5 ± 15 years, body mass index 28.7 ± 6.3 kg/m2 were screened, and 46 screened positive for sarcopenia, with a lower median HGS (19.3 (14.2–24.7) vs 25.6 (19.7–32) kg) and greater body fat (38.3 ± 11.5 vs 30.6 ± 11.5%), both p < 0.001,, with more non-white ethnicity (63 vs 44%), p < 0.05, but there were no other differences. Step-wise adding HGS, and then APMI cut offs, the prevalence of sarcopenia fell from 31.5% to 20.7–24.7% and 2.8–4.8% respectively, with 45.5–62.8% having reduced HGS strength and 11.0–28.1% reduced APMI, depending on which guidelines were applied. Using the most recent European, and ethnicity adjusted cut-off values then there were no statistical differences in the prevalence of sarcopenia with or without the Sarc-F screening tool. Conclusions: By starting with the Sarc-F screening tool, a number of our patients with CKD would then have been excluded from subsequent investigation for sarcopenia. However, overall screening with the Sarc-F tool did not lead to a significant difference in the prevalence of sarcopenia, when using current and ethnicity adjusted guidelines, compared to combining HGS and APMI alone.
| Type: | Article |
|---|---|
| Title: | Screening Tests for Sarcopenia in Patients with Chronic Kidney Disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ncp.10597 |
| Publisher version: | https://doi.org/10.1002/ncp.10597 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Nutrition & Dietetics, bioimpedance, chronic kidney disease, hand grip strength, muscle mass, nutrition assessment, nutrition screening, sarcopenia, BODY-COMPOSITION, CONSENSUS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10135474 |
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