Pallett, LJ;
Dimeloe, S;
Sinclair, LV;
Byrne, AJ;
Schurich, A;
(2021)
A glutamine 'tug-of-war': targets to manipulate glutamine metabolism for cancer immunotherapy.
Immunotherapy Advances
, 1
(1)
, Article ltab010. 10.1093/immadv/ltab010.
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Abstract
Within the tumour microenvironment (TME), there is a cellular ‘tug-of-war’ for glutamine, the most abundant amino acid in the body. This competition is most evident when considering the balance between a successful anti-tumour immune response and the uncontrolled growth of tumour cells that are addicted to glutamine. The differential effects of manipulating glutamine abundance in individual cell types is an area of intense research and debate. Here, we discuss some of the current strategies in development altering local glutamine availability focusing on inhibition of enzymes involved in the utilisation of glutamine and its uptake by cells in the TME. Further studies are urgently needed to complete our understanding of glutamine metabolism, to provide critical insights into the pathways that represent promising targets and for the development of novel therapeutic strategies for the treatment of advanced or drug resistant cancers.
| Type: | Article |
|---|---|
| Title: | A glutamine 'tug-of-war': targets to manipulate glutamine metabolism for cancer immunotherapy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/immadv/ltab010 |
| Publisher version: | https://doi.org/10.1093/immadv/ltab010 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Immunology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | glutamine, T cells, cancer immunotherapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10135152 |
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