Joshi, A;
Vishnu G. K., A;
Sakorikar, T;
Kamal, AM;
Vaidya, JS;
Pandya, HJ;
(2021)
Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects.
Nanoscale Advances
10.1039/d1na00453k.
(In press).
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Abstract
Timely and accurate diagnosis of breast cancer is essential for efficient treatment and the best possible survival rates. Biosensors have emerged as a smart diagnostic platform for the detection of biomarkers specific to the onset, recurrence, and therapeutic drug monitoring of breast cancer. There have been exciting recent developments, including significant improvements in the validation, sensitivity, specificity, and integration of sample processing steps to develop point-of-care (POC) integrated micro-total analysis systems for clinical settings. The present review highlights various biosensing modalities (electrical, optical, piezoelectric, mass, and acoustic sensing). It provides deep insights into their design principles, signal amplification strategies, and comparative performance analysis. Finally, this review emphasizes the status of existing integrated micro-total analysis systems (μ-TAS) for personalized breast cancer therapeutics and associated challenges and outlines the approach required to realize their successful translation into clinical settings.
| Type: | Article |
|---|---|
| Title: | Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d1na00453k |
| Publisher version: | https://doi.org/10.1039/D1NA00453K |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. |
| Keywords: | Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Chemistry, Science & Technology - Other Topics, Materials Science, SURFACE-PLASMON RESONANCE, FREE ELECTROCHEMICAL DETECTION, DOPED SILICA NANOPARTICLES, LABEL-FREE DETECTION, SIGNAL AMPLIFICATION, GROWTH-FACTOR, ULTRASENSITIVE DETECTION, COLORIMETRIC DETECTION, QUANTUM DOTS, CARBON DOTS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134536 |
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