Pontzer, H;
Yamada, Y;
Sagayama, H;
Ainslie, PN;
Andersen, LF;
Anderson, LJ;
Arab, L;
... Speakman, JR; + view all
(2021)
Daily energy expenditure through the human life course.
Science
, 373
(6556)
pp. 808-812.
10.1126/science.abe5017.
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Abstract
Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
| Type: | Article |
|---|---|
| Title: | Daily energy expenditure through the human life course |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/science.abe5017 |
| Publisher version: | http://dx.doi.org/10.1126/science.abe5017 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CELLULAR-LEVEL APPROACH, BASAL METABOLIC-RATE, PHYSICAL-ACTIVITY, LONGITUDINAL ASSESSMENT, SLEEP DURATION, ORGAN SIZE, WATER, CHILDREN, REQUIREMENTS, DEPOSITION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134246 |
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