SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability

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SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability

Shorthouse, D; Hall, BA; (2021) SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability. Journal of Chemical Information and Modeling , 61 (9) pp. 4152-4155. 10.1021/acs.jcim.1c00990. Green open access

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Abstract

The emergence of variants of SARS-CoV-2 with mutations in their spike protein are a major cause for concern for the efficacy of vaccines and control of the pandemic. We show that mutations in the spike protein of SARS-CoV-2 are selecting for amino acid changes that result in a more thermodynamically stable protein than expected from background. We suggest that the computationally efficient analysis of mutational stability may aid in early screening of variants.

Type:	Article
Title:	SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1021/acs.jcim.1c00990
Publisher version:	https://doi.org/10.1021/acs.jcim.1c00990
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords:	Genetics, Protein structure, SARS-CoV-2, Spike protein, Stability
UCL classification:	UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI:	https://discovery.ucl.ac.uk/id/eprint/10134048