Shorthouse, D;
Hall, BA;
(2021)
SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability.
Journal of Chemical Information and Modeling
, 61
(9)
pp. 4152-4155.
10.1021/acs.jcim.1c00990.
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Abstract
The emergence of variants of SARS-CoV-2 with mutations in their spike protein are a major cause for concern for the efficacy of vaccines and control of the pandemic. We show that mutations in the spike protein of SARS-CoV-2 are selecting for amino acid changes that result in a more thermodynamically stable protein than expected from background. We suggest that the computationally efficient analysis of mutational stability may aid in early screening of variants.
| Type: | Article |
|---|---|
| Title: | SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.jcim.1c00990 |
| Publisher version: | https://doi.org/10.1021/acs.jcim.1c00990 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Genetics, Protein structure, SARS-CoV-2, Spike protein, Stability |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134048 |
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