Venturini, C;
Houldcroft, CJ;
Lazareva, A;
Wegner, F;
Morfopoulou, S;
Amrolia, PJ;
Golwala, Z;
... Breuer, J; + view all
(2021)
Epstein-Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV.
British Journal of Haematology
10.1111/bjh.17790.
(In press).
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Abstract
Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV+ haematological clones that are lost on successful treatment.
| Type: | Article |
|---|---|
| Title: | Epstein-Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bjh.17790 |
| Publisher version: | https://doi.org/10.1111/bjh.17790 |
| Language: | English |
| Additional information: | © 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Epstein-Barr virus, chronic active EBV, defective viral genome |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10133791 |
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