Renton, J;
Page, KM;
(2021)
Cooperative success in epithelial public goods games.
Journal of Theoretical Biology
, 528
, Article 110838. 10.1016/j.jtbi.2021.110838.
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Abstract
Cancer cells obtain mutations which rely on the production of diffusible growth factors to confer a fitness benefit. These mutations can be considered cooperative, and studied as public goods games within the framework of evolutionary game theory. The population structure, benefit function and update rule all influence the evolutionary success of cooperators. We model the evolution of cooperation in epithelial cells using the Voronoi tessellation model. Unlike traditional evolutionary graph theory, this allows us to implement global updating, for which birth and death events are spatially decoupled. We compare, for a sigmoid benefit function, the conditions for cooperation to be favoured and/or beneficial for well-mixed and structured populations. We find that when population structure is combined with global updating, cooperation is more successful than if there were local updating or the population were well-mixed. Interestingly, the qualitative behaviour for the well-mixed population and the Voronoi tessellation model is remarkably similar, but the latter case requires significantly lower incentives to ensure cooperation.
| Type: | Article |
|---|---|
| Title: | Cooperative success in epithelial public goods games |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jtbi.2021.110838 |
| Publisher version: | https://doi.org/10.1016/j.jtbi.2021.110838 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published by Elsevier Ltd under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Multiplayer games, Cooperation, Evolutionary game theory, Voronoi tessellation, Epithelial automata |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10133379 |
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