Herrera, SC;
Sainz de la Maza, D;
Grmai, L;
Margolis, S;
Plessel, R;
Burel, M;
O’Connor, M;
... Bach, EA; + view all
(2021)
Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
Developmental Cell
10.1016/j.devcel.2021.07.010.
(In press).
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Abstract
Aging causes stem cell dysfunction as a result of extrinsic and intrinsic changes. Decreased function of the stem cell niche is an important contributor to this dysfunction. We use the Drosophila testis to investigate what factors maintain niche cells. The testis niche comprises quiescent “hub” cells and supports two mitotic stem cell pools: germline stem cells and somatic cyst stem cells (CySCs). We identify the cell-cycle-responsive Dp/E2f1 transcription factor as a crucial non-autonomous regulator required in CySCs to maintain hub cell quiescence. Dp/E2f1 inhibits local Activin ligands through production of the Activin antagonist Follistatin (Fs). Inactivation of Dp/E2f1 or Fs in CySCs or promoting Activin receptor signaling in hub cells causes transdifferentiation of hub cells into fully functional CySCs. This Activin-dependent communication between CySCs and hub regulates the physiological decay of the niche with age and demonstrates that hub cell quiescence results from signals from surrounding stem cells.
| Type: | Article |
|---|---|
| Title: | Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.devcel.2021.07.010 |
| Publisher version: | https://doi.org/10.1016/j.devcel.2021.07.010 |
| Language: | English |
| Additional information: | © 2021 The Authors. Published by Elsevier Inc. under a Creative Commons license (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Drosophila, testis, cyst stem cell, niche, quiescence, transdifferentiation, Activin, Follistatin, Dp/E2f, aging, fertility |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10132962 |
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