Damilos, S;
Alissandratos, I;
Panariello, L;
Radhakrishnan, ANP;
Cao, E;
Wu, G;
Besenhard, MO;
... Gavriilidis, A; + view all
(2021)
Continuous citrate-capped gold nanoparticle synthesis in a two-phase flow reactor.
Journal of Flow Chemistry
10.1007/s41981-021-00172-3.
(In press).
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Gavriilidis_Continuous citrate-capped gold nanoparticle synthesis in a two-phase flow reactor_AOP.pdf - Published Version Download (7MB) | Preview |
Abstract
A continuous manufacturing platform was developed for the synthesis of aqueous colloidal 10–20 nm gold nanoparticles (Au NPs) in a flow reactor using chloroauric acid, sodium citrate and citric acid at 95 oC and 2.3 bar(a) pressure. The use of a two-phase flow system – using heptane as the continuous phase – prevented fouling on the reactor walls, while improving the residence time distribution. Continuous syntheses for up to 2 h demonstrated its potential application for continuous manufacturing, while live quality control was established using online UV-Vis photospectrometry that monitored the particle size and process yield. The synthesis was stable and reproducible over time for gold precursor concentration above 0.23 mM (after mixing), resulting in average particle size between 12 and 15 nm. A hydrophobic membrane separator provided successful separation of the aqueous and organic phases and collection of colloidal Au NPs in flow. Process yield increased at higher inlet flow rates (from 70 % to almost 100 %), due to lower residence time of the colloidal solution in the separator resulting in less fouling in the PTFE membrane. This study addresses the challenges for the translation of the synthesis from batch to flow and provides tools for the development of a continuous manufacturing platform for gold nanoparticles.
| Type: | Article |
|---|---|
| Title: | Continuous citrate-capped gold nanoparticle synthesis in a two-phase flow reactor |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s41981-021-00172-3 |
| Publisher version: | https://doi.org/10.1007/s41981-021-00172-3 |
| Language: | English |
| Additional information: | © 2021 Springer Nature Switzerland AG. Part of Springer Nature. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Nanomaterials, Continuous manufacturing, Online analysis, Segmented flow, Phase separation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10132957 |
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