Vila-Comamala, J; Romano, L; Jefimovs, K; Dejea, H; Bonnin, A; Cook, AC; Planinc, I; ... Stampanoni, M; + view all Vila-Comamala, J; Romano, L; Jefimovs, K; Dejea, H; Bonnin, A; Cook, AC; Planinc, I; Cikes, M; Wang, Z; Stampanoni, M; - view fewer (2021) High sensitivity X-ray phase contrast imaging by laboratory grating-based interferometry at high Talbot order geometry. Optics Express , 29 (2) pp. 2049-2064. 10.1364/OE.414174.

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Abstract

X-ray phase contrast imaging is a powerful analysis technique for materials science and biomedicine. Here, we report on laboratory grating-based X-ray interferometry employing a microfocus X-ray source and a high Talbot order (35th) asymmetric geometry to achieve high angular sensitivity and high spatial resolution X-ray phase contrast imaging in a compact system (total length <1 m). The detection of very small refractive angles (∼50 nrad) at an interferometer design energy of 19 keV was enabled by combining small period X-ray gratings (1.0, 1.5 and 3.0 µm) and a single-photon counting X-ray detector (75 µm pixel size). The performance of the X-ray interferometer was fully characterized in terms of angular sensitivity and spatial resolution. Finally, the potential of laboratory X-ray phase contrast for biomedical imaging is demonstrated by obtaining high resolution X-ray phase tomographies of a mouse embryo embedded in solid paraffin and a formalin-fixed full-thickness sample of human left ventricle in water with a spatial resolution of 21.5 µm.

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