Xiong, S;
Lyu, Y;
Davenport, A;
Choy, KL;
(2021)
Chitosan based fibrous absorbents for indoxyl sulfate sorption.
Materials Letters
, 293
, Article 129744. 10.1016/j.matlet.2021.129744.
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Abstract
Standard dialyzer membranes, designed for diffusive clearance, do not effectively clear protein-bound uremic toxins, such as indoxyl sulfate (IS). To increase protein-bound toxins removal, absorbents require a high specific surface area to achieve effective size-coupling removal of target toxins. However, the toxicity of a molecule is not necessarily determined by size alone. As proof of concept, we report on an electrospun polycaprolactone/chitosan (PCL/CS) fibrous absorbent for IS removal based on chemical structural interaction. A single unit (20 mm in length) of our PCL/CS absorbent achieved a 28% clearance of IS within an hour at both 40 mg/L and 5 mg/L concentrations in a single pass model. This fibrous absorbent structure offers new thoughts on absorbent design.
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