Chitosan based fibrous absorbents for indoxyl sulfate sorption

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Chitosan based fibrous absorbents for indoxyl sulfate sorption

Xiong, S; Lyu, Y; Davenport, A; Choy, KL; (2021) Chitosan based fibrous absorbents for indoxyl sulfate sorption. Materials Letters , 293 , Article 129744. 10.1016/j.matlet.2021.129744. Green open access

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Abstract

Standard dialyzer membranes, designed for diffusive clearance, do not effectively clear protein-bound uremic toxins, such as indoxyl sulfate (IS). To increase protein-bound toxins removal, absorbents require a high specific surface area to achieve effective size-coupling removal of target toxins. However, the toxicity of a molecule is not necessarily determined by size alone. As proof of concept, we report on an electrospun polycaprolactone/chitosan (PCL/CS) fibrous absorbent for IS removal based on chemical structural interaction. A single unit (20 mm in length) of our PCL/CS absorbent achieved a 28% clearance of IS within an hour at both 40 mg/L and 5 mg/L concentrations in a single pass model. This fibrous absorbent structure offers new thoughts on absorbent design.

Type:	Article
Title:	Chitosan based fibrous absorbents for indoxyl sulfate sorption
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1016/j.matlet.2021.129744
Publisher version:	http://dx.doi.org/10.1016/j.matlet.2021.129744
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Fibrous materials, Absorbent, Ureamic toxin removal, Chitosan, Electrospinning
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery
URI:	https://discovery.ucl.ac.uk/id/eprint/10132104