Kirilina, E;
Helbling, S;
Morawski, M;
Pine, K;
Reimann, K;
Jankuhn, S;
Dinse, J;
... Weiskopf, N; + view all
(2020)
Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping.
Science Advances
, 6
(41)
, Article eaaz9281. 10.1126/sciadv.aaz9281.
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Abstract
Superficial white matter (SWM) contains the most cortico-cortical white matter connections in the human brain encompassing the short U-shaped association fibers. Despite its importance for brain connectivity, very little is known about SWM in humans, mainly due to the lack of noninvasive imaging methods. Here, we lay the groundwork for systematic in vivo SWM mapping using ultrahigh resolution 7 T magnetic resonance imaging. Using biophysical modeling informed by quantitative ion beam microscopy on postmortem brain tissue, we demonstrate that MR contrast in SWM is driven by iron and can be linked to the microscopic iron distribution. Higher SWM iron concentrations were observed in U-fiber–rich frontal, temporal, and parietal areas, potentially reflecting high fiber density or late myelination in these areas. Our SWM mapping approach provides the foundation for systematic studies of interindividual differences, plasticity, and pathologies of this crucial structure for cortico-cortical connectivity in humans.
| Type: | Article |
|---|---|
| Title: | Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/sciadv.aaz9281 |
| Publisher version: | http://dx.doi.org/10.1126/sciadv.aaz9281 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | MAGNETIC-SUSCEPTIBILITY, MULTI-ECHO, IRON, MRI, ORIENTATION, PHASE, CONNECTIONS, MICROSCOPY, FREQUENCY, FERRITIN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10131214 |
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