Neffe, AT;
Zhang, Q;
Hommes-Schattmann, PJ;
Wang, W;
Xu, X;
Ahmad, BS;
Williams, GR;
(2021)
Functionalizable coaxial PLLA/PDLA nanofibers with stereocomplexes at the internal interface.
Journal of Materials Research
10.1557/s43578-021-00260-z.
(In press).
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Abstract
Multifunctionality of electrospun polylactic acid (PLA) nonwovens was generated by the morphological design of nanofibers. Coaxial fibers with a lower number average molar mass Mn PLLA core and a higher Mn PDLA shell form PDLA–PLLA stereocrystals at the interface, induced by annealing. In tensile tests under physiological conditions, the core–shell fibers with higher crystallinity (22% compared to 11–14%) had lower Young’s moduli E (9 ± 1 MPa) and lower elongation at break εb (26 ± 3%) than PDLA alone (E = 31 ± 9 MPa, εb = 80 ± 5%), which can be attributed to simultaneous crystallization and relaxation effects. Gelatin incorporated in the PDLA phase was presented on the outer surface providing a biointerface putatively favorable for cell adherence. Gelatin incorporation did not influence the crystallization behavior but slightly lowered Tg (60 → 54 °C). Employing exclusively polymers established in the clinic, multifunctionality was generated by design.
| Type: | Article |
|---|---|
| Title: | Functionalizable coaxial PLLA/PDLA nanofibers with stereocomplexes at the internal interface |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1557/s43578-021-00260-z |
| Publisher version: | https://doi.org/10.1557/s43578-021-00260-z |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. |
| Keywords: | Biomaterial; Blend; Crystallization; Degradable; Polymer; Renewable |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10131185 |
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