Leitch, JA;
Smallman, HR;
Browne, DL;
(2021)
Solvent-Minimized Synthesis of 4CzIPN and Related Organic Fluorophores via Ball Milling.
The Journal of Organic Chemistry
, 86
(20 14095)
pp. 14095-14101.
10.1021/acs.joc.1c01233.
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Abstract
The mechanochemical synthesis of 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile and related organic fluorophores/photocatalysts via a solvent-minimized four-fold SNAr pathway is herein described. Employing sodium tert-butoxide as base, and negating the need for any air/moisture-sensitive reaction set-ups, a selection of organic dyes was synthesized in just 1 h using this ball-milling technique. Furthermore, the transformation was then showcased on a multigram scale.
| Type: | Article |
|---|---|
| Title: | Solvent-Minimized Synthesis of 4CzIPN and Related Organic Fluorophores via Ball Milling |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.joc.1c01233 |
| Publisher version: | https://doi.org/10.1021/acs.joc.1c01233 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Column chromatography, Silica, Aromatic compounds, Organic synthesis, Fluorophores |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10130572 |
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