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Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions

Smallman, HR; Leitch, JA; McBride, T; Ley, SV; Browne, D; (2021) Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions. Tetrahedron , 93 , Article 132305. 10.1016/j.tet.2021.132305. Green open access

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Abstract

Continuous flow systems offer unique benefits in the generation and manipulation of sensitive reactive intermediates such as ketenes. To this end, the last decade has witnessed the development of continuous flow methods for the generation of ketenes by means of chemical, thermal, and photochemical activation modes. This perspective covers these advances and the downstream reactivity of ketenes in continuous flow technology.

Type: Article
Title: Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tet.2021.132305
Publisher version: https://doi.org/10.1016/j.tet.2021.132305
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Reactive intermediates, Continuous flow, Ketene, Acyl-ketene, Photochemistry
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10129648
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