Ali, M; VandenBerg, K; Williams, LJ; Williams, LR; Abo, M; Becker, F; Bowen, A; ... Brady, MC; + view all Ali, M; VandenBerg, K; Williams, LJ; Williams, LR; Abo, M; Becker, F; Bowen, A; Brandenburg, C; Breitenstein, C; Bruehl, S; Copland, DA; Cranfill, TB; Di Pietro-Bachmann, M; Enderby, P; Fillingham, J; Galli, FL; Gandolfi, M; Glize, B; Godecke, E; Hawkins, N; Hilari, K; Hinckley, J; Horton, S; Howard, D; Jaecks, P; Jefferies, E; Jesus, LMT; Kambanaros, M; Kang, EK; Khedr, EM; Kong, AP-H; Kukkonen, T; Laganaro, M; Ralph, MAL; Laska, AC; Leemann, B; Leff, AP; Lima, RR; Lorenz, A; Mac Whinney, B; Marshall, RS; Meinzer, M; Nilipour, R; Noe, E; Paik, N-J; Palmer, R; Papathanasiou, I; Patricio, BF; Martins, IP; Price, C; Jakovac, TP; Rochon, E; Rose, ML; Rosso, C; Rubi-Fessen, I; Ruiter, MB; Snell, C; Stahl, B; Szaflarski, JP; Thomas, SA; Van De Sandt-Koenderman, M; van der Meulen, I; Visch-Brink, E; Worrall, L; Wright, HH; Brady, MC; - view fewer (2021) Predictors of Poststroke Aphasia Recovery A Systematic Review-Informed Individual Participant Data Meta-Analysis. Stroke , 52 (5) pp. 1778-1787. 10.1161/STROKEAHA.120.031162.

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Abstract

Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. / Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. / Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0–20.9], +6.1 correct on AAT Token Test [CI, 3.2–8.9]; +9.3 Boston Naming Test points [CI, 4.7–13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5–1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9–24.4]; +5.3 correct on AAT Token Test [CI, 1.7–8.8]; +11.1 Boston Naming Test points [CI, 5.7–16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7–1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. / Conclusions: Earlier intervention for poststroke aphasia was crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.

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