Pagnamenta, AT;
Wei, W;
Rahman, S;
Chinnery, PF;
(2021)
Biparental inheritance of mitochondrial DNA revisited.
Nature Reviews Genetics
, 22
pp. 477-478.
10.1038/s41576-021-00380-6.
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Abstract
Evidence for a biparental mode of mitochondrial DNA (mtDNA) inheritance has been sparse and remains controversial. Recent studies using a range of complementary techniques do not support paternal transmission of mtDNA and highlight the co-amplification of rare, concatenated nuclear mtDNA segments as a technical artefact that may explain previous observations.
| Type: | Article |
|---|---|
| Title: | Biparental inheritance of mitochondrial DNA revisited |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41576-021-00380-6 |
| Publisher version: | https://doi.org/10.1038/s41576-021-00380-6 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Genetics, Mitochondrial genome, Sequencing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10128999 |
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