Emmerzaal, TL;
Nijkamp, G;
Veldic, M;
Rahman, S;
Andreazza, AC;
Morava, E;
Rodenburg, RJ;
(2021)
Effect of neuropsychiatric medications on mitochondrial function; for better or for worse.
Neuroscience & Biobehavioral Reviews
, 127
pp. 555-571.
10.1016/j.neubiorev.2021.05.001.
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Abstract
Individuals with mitochondrial disease often present with psychopathological comorbidity, and mitochondrial dysfunction has been proposed as the underlying pathobiology in various psychiatric disorders. Several studies have suggested that medications used to treat neuropsychiatric disorders could directly influence mitochondrial function. This review provides a comprehensive overview of the effect of these medications on mitochondrial function. We collected preclinical information on six major groups of antidepressants and other neuropsychiatric medications and found that the majority of these medications either positively influenced mitochondrial function or showed mixed effects. Only amitriptyline, escitalopram, and haloperidol were identified as having exclusively adverse effects on mitochondrial function. In the absence of formal clinical trials, and until such trials are completed, the data from preclinical studies reported and discussed here could inform medication prescribing practices for individuals with psychopathology and impaired mitochondrial function in the underlying pathology.
| Type: | Article |
|---|---|
| Title: | Effect of neuropsychiatric medications on mitochondrial function; for better or for worse |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neubiorev.2021.05.001 |
| Publisher version: | https://doi.org/10.1016/j.neubiorev.2021.05.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Antidepressive Agents, Drugs, Electron Transport Chain Complex Proteins, Mitochondria, in vivo studies |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10128974 |
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