Ketteler, R;
Tooze, SA;
(2021)
ATG4: More Than a Protease?
Trends in Cell Biology
, 31
(7)
pp. 515-516.
10.1016/j.tcb.2021.04.003.
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Abstract
The ATG4 proteases are key regulators of autophagy. Until recently it was thought that their main function was to mediate the processing of ATG8 family members. A new study by Nguyen et al. reveals a role for ATG4s, independent of their catalytic activity, and proposes novel functions in mediating lipid transfer and mitophagy.
| Type: | Article |
|---|---|
| Title: | ATG4: More Than a Protease? |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tcb.2021.04.003 |
| Publisher version: | https://doi.org/10.1016/j.tcb.2021.04.003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | ARFIP2, ATG9A, GABARAP, LC3, autophagy, mitophagy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10128350 |
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