Haider, T;
Snetkov, X;
Jolly, C;
(2021)
HIV envelope tail truncation confers resistance to SERINC5 restriction.
Proceedings of the National Academy of Sciences
, 118
(21)
, Article e2101450118. 10.1073/pnas.2101450118.
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Abstract
SERINCs and IFITMs are potent lentiviral restriction factors that inhibit infection by blocking viral entry into cells. Specifically, SERINCs inhibit viral fusion by targeting the envelope glycoprotein (Env) by a mechanism that remains incompletely understood. Here, we report that truncation of the Env cytoplasmic tail (CT) of HIV-1 and HIV-2 confers complete resistance to SERINC and IFITM restriction. Notably, while the EnvCT of HIV-1 is necessary for viral replication in T cells, HIV-2 does not require the EnvCT. Our data suggest a mechanism by which human lentiviruses can evade restriction that is mediated by the EnvCT but reveal key differences in the likely fitness cost imposed by this on pandemic HIV-1 and nonpandemic HIV-2.
| Type: | Article |
|---|---|
| Title: | HIV envelope tail truncation confers resistance to SERINC5 restriction |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1073/pnas.2101450118 |
| Publisher version: | http://dx.doi.org/10.1073/pnas.2101450118 |
| Language: | English |
| Additional information: | Copyright © 2021 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10128272 |
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