Kuppuswamy, A;
(2021)
The Neurobiology of Pathological Fatigue: New Models, New Questions.
The Neuroscientist
10.1177/1073858420985447.
(In press).
Preview |
Text
1073858420985447.pdf - Published Version Download (417kB) | Preview |
Abstract
The last decade has seen the emergence of new theoretical frameworks to explain pathological fatigue, a much neglected, yet highly significant symptom across a wide range of diseases. While the new models of fatigue provide new hypotheses to test, they also raise a number of questions. The primary purpose of this essay is to examine the predictions of three recently proposed models of fatigue, the overlap and differences between them, and the evidence from diseases that may lend support to the models of fatigue. I also present expansions for the sensory attenuation model of fatigue. Further questions examined here are the following: What are the neural substrates of fatigue? How can sensory attenuation, which underpins agency also explain fatigue? Are fatigue and agency related?
| Type: | Article |
|---|---|
| Title: | The Neurobiology of Pathological Fatigue: New Models, New Questions |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/1073858420985447 |
| Publisher version: | https://doi.org/10.1177/1073858420985447 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | agency, exteroception, fatigue, interoception, multiple sclerosis, Parkinson’s, sensory attenuation, stroke |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10128140 |
Archive Staff Only
 |
View Item |
