Molloy, SF;
Ross, B;
Kanyama, C;
Mfinanga, S;
Lesikari, S;
Heyderman, RS;
Kalata, N;
... Bicanic, T; + view all
(2021)
Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Open Forum Infectious Diseases
, 8
(4)
, Article ofab066. 10.1093/ofid/ofab066.
Preview |
Text
ofab066.pdf - Published Version Download (406kB) | Preview |
Abstract
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.
| Type: | Article |
|---|---|
| Title: | Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ofid/ofab066 |
| Publisher version: | https://doi.org/10.1093/ofid/ofab066 |
| Language: | English |
| Additional information: | © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Cryptococcal meningitis, fungal burden, HIV, raised intracranial pressure, visual loss |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10127412 |
Archive Staff Only
 |
View Item |
