Aytac-Kipergil, E;
Desjardins, AE;
Treeby, BE;
Noimark, S;
Parkin, IP;
Alles, EJ;
(2021)
Modelling and measurement of laser-generated focused ultrasound: Can interventional transducers achieve therapeutic effects?
The Journal of the Acoustical Society of America
, 149
(4)
pp. 2732-2742.
10.1121/10.0004302.
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Abstract
Laser-generated focused ultrasound (LGFU) transducers used for ultrasound therapy commonly have large diameters (6–15 mm), but smaller lateral dimensions (<4 mm) are required for interventional applications. To address the question of whether miniaturized LGFU transducers could generate sufficient pressure at the focus to enable therapeutic effects, a modelling and measurement study is performed. Measurements are carried out for both linear and nonlinear propagation for various illumination schemes and compared with the model. The model comprises several innovations. First, the model allows for radially varying acoustic input distributions on the surface of the LGFU transducer, which arise from the excitation light impinging on the curved transducer surfaces. This realistic representation of the source prevents the overestimation of the achievable pressures (shown here to be as high as 1.8 times). Second, an alternative inverse Gaussian illumination paradigm is proposed to achieve higher pressures; a 35% increase is observed in the measurements. Simulations show that LGFU transducers as small as 3.5 mm could generate sufficient peak negative pressures at the focus to exceed the cavitation threshold in water and blood. Transducers of this scale could be integrated with interventional devices, thereby opening new opportunities for therapeutic applications from inside the body.
| Type: | Article |
|---|---|
| Title: | Modelling and measurement of laser-generated focused ultrasound: Can interventional transducers achieve therapeutic effects? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1121/10.0004302 |
| Publisher version: | http://dx.doi.org/10.1121/10.0004302 |
| Language: | English |
| Additional information: | © 2021 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). https://doi.org/10.1121/10.0004302 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10126814 |
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