Renard, HF;
Boucrot, E;
(2021)
Unconventional endocytic mechanisms.
Current Opinion in Cell Biology
, 71
pp. 120-129.
10.1016/j.ceb.2021.03.001.
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Abstract
Endocytosis mediates the uptake of extracellular proteins, micronutrients and transmembrane cell surface proteins. Importantly, many viruses, toxins and bacteria hijack endocytosis to infect cells. The canonical pathway is clathrin-mediated endocytosis (CME) and is active in all eukaryotic cells to support critical house-keeping functions. Unconventional mechanisms of endocytosis exit in parallel of CME, to internalize specific cargoes and support various cellular functions. These clathrin-independent endocytic (CIE) routes use three distinct mechanisms: acute signaling-induced membrane remodeling drives macropinocytosis, activity-dependent bulk endocytosis (ADBE), massive endocytosis (MEND) and EGFR non-clathrin endocytosis (EGFR-NCE). Cargo capture and local membrane deformation by cytosolic proteins is used by fast endophilin-mediated endocytosis (FEME), IL-2Rβ endocytosis and ultrafast endocytosis at synapses. Finally, the formation of endocytic pits by clustering of extracellular lipids or cargoes according to the Glycolipid-Lectin (GL-Lect) hypothesis mediates the uptake of SV40 virus, Shiga and cholera toxins, and galectin-clustered receptors by the CLIC/GEEC and the endophilin-A3-mediated CIE.
| Type: | Article |
|---|---|
| Title: | Unconventional endocytic mechanisms |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceb.2021.03.001 |
| Publisher version: | https://doi.org/10.1016/j.ceb.2021.03.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Endocytosis, Clathrin, Clathrin-mediated endocytosis, Clathrin-independent endocytosis, Cargoes, Receptors, Lipids, Glycosylphosphatidylinositol-anchored proteins, Macropinocytosis, Activity-dependent bulk endocytosis, Massive Endocytosis, EGFR Non-Clathrin endocytosis, Interleukin-2 receptor endocytosis, Fast endophilin-mediated endocytosis (FEME), Ultrafast endocytosis, Glycolipid-Lectin hypothesis, Clathrin-independent carriers/GPI-AP-enriched early endosomal compartments (CLIC/GEEC), Endophilin-A3/Galectin-8-mediated endocytosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10126691 |
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