Mercadante, V;
Scarpa, E;
De Matteis, V;
Rizzello, L;
Poma, A;
(2021)
Engineering Polymeric Nanosystems against Oral Diseases.
Molecules
, 26
(8)
, Article 2229. 10.3390/molecules26082229.
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Abstract
Nanotechnology and nanoparticles (NPs) are at the forefront of modern research, particularly in the case of healthcare therapeutic applications. Polymeric NPs, specifically, hold high promise for these purposes, including towards oral diseases. Careful optimisation of the production of polymeric NPs, however, is required to generate a product which can be easily translated from a laboratory environment to the actual clinical usage. Indeed, considerations such as biocompatibility, biodistribution, and biodegradability are paramount. Moreover, a pre-clinical assessment in adequate in vitro, ex vivo or in vivo model is also required. Last but not least, considerations for the scale-up are also important, together with an appropriate clinical testing pathway. This review aims to eviscerate the above topics, sourcing at examples from the recent literature to put in context the current most burdening oral diseases and the most promising polymeric NPs which would be suitable against them.
| Type: | Article |
|---|---|
| Title: | Engineering Polymeric Nanosystems against Oral Diseases |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/molecules26082229 |
| Publisher version: | https://doi.org/10.3390/molecules26082229 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| Keywords: | Nanotechnology; polymeric nanoparticles; oral diseases; oral medicine; caries; restorative dentistry; endodontology; periodontology; oral cancer; pre-clinical models; clinical studies |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10126380 |
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