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Archaeogenomic distinctiveness of the Isthmo-Colombian area

Capodiferro, MR; Aram, B; Raveane, A; Rambaldi Migliore, N; Colombo, G; Ongaro, L; Rivera, J; ... Achilli, A; + view all (2021) Archaeogenomic distinctiveness of the Isthmo-Colombian area. Cell , 184 (7) 1706-1723.e24. 10.1016/j.cell.2021.02.040. Green open access

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Abstract

The recently enriched genomic history of Indigenous groups in the Americas is still meager concerning continental Central America. Here, we report ten pre-Hispanic (plus two early colonial) genomes and 84 genome-wide profiles from seven groups presently living in Panama. Our analyses reveal that pre-Hispanic demographic events contributed to the extensive genetic structure currently seen in the area, which is also characterized by a distinctive Isthmo-Colombian Indigenous component. This component drives these populations on a specific variability axis and derives from the local admixture of different ancestries of northern North American origin(s). Two of these ancestries were differentially associated to Pleistocene Indigenous groups that also moved into South America, leaving heterogenous genetic footprints. An additional Pleistocene ancestry was brought by a still unsampled population of the Isthmus (UPopI) that remained restricted to the Isthmian area, expanded locally during the early Holocene, and left genomic traces up to the present day.

Type: Article
Title: Archaeogenomic distinctiveness of the Isthmo-Colombian area
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2021.02.040
Publisher version: https://doi.org/10.1016/j.cell.2021.02.040
Language: English
Additional information: © 2021 The Authors. Published by Elsevier Inc. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Central America, Isthmian populations, Panama, ancient and modern DNA, anthropology and history, archaeogenomics, archaeology, genomic variation, indigenous Americans, population genetics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10125858
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