Hockman, D;
Burns, AJ;
Schlosser, G;
Gates, KP;
Jevans, B;
Mongera, A;
Fisher, S;
... Baker, CVH; + view all
(2017)
Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.
eLife
, 6
, Article e21231. 10.7554/eLife.21231.
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Abstract
The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ‘neuroepithelial cells’ (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.
| Type: | Article |
|---|---|
| Title: | Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.21231 |
| Publisher version: | https://doi.org/10.7554/eLife.21231 |
| Language: | English |
| Additional information: | © Copyright Hockman et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10125769 |
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