Hutter, J;
Ho, A;
Jackson, LH;
Slator, PJ;
Chappell, LC;
Hajnal, JV;
Rutherford, MA;
(2021)
An efficient and combined placental T1-ADC acquisition in pregnancies with and without pre-eclampsia.
Magnetic Resonance in Medicine
10.1002/mrm.28809.
(In press).
Preview |
Text
Slator_An efficient and combined placental T1 -ADC acquisition in pregnancies with and without pre-eclampsia_AOP.pdf - Published Version Download (1MB) | Preview |
Abstract
PURPOSE: To provide a new approach to jointly assess microstructural and molecular properties of the human placenta in vivo fast and efficiently and to present initial evidence in cohorts of healthy pregnancies and those affected by pre-eclampsia. METHODS: Slice and diffusion preparation shuffling, built on the previously proposed ZEBRA method, is presented as a robust and fast way to obtain urn:x-wiley:07403194:media:mrm28809:mrm28809-math-0003 and apparent diffusivity coefficient (ADC) values. Joint modeling and evaluation is performed on a cohort of healthy and pre-eclamptic participants at 3T. RESULTS: The datasets show the ability to obtain robust and fast urn:x-wiley:07403194:media:mrm28809:mrm28809-math-0004-ADC measurements. Significant decay over gestation in urn:x-wiley:07403194:media:mrm28809:mrm28809-math-0005 (−11 ms/week, urn:x-wiley:07403194:media:mrm28809:mrm28809-math-0006) and a trend toward significance in ADC (−0.23 mm/urn:x-wiley:07403194:media:mrm28809:mrm28809-math-0007/week, P = .08) values can be observed in a control cohort. Values for the pre-eclamptic pregnancies show a negative trend for both ADC and T1. CONCLUSIONS: The presented sequence allows the simultaneous acquisition of 2 of the most promising quantitative parameters to study placental insufficiency—identified individually as relevant in previous studies—in under 2 minutes. This allows dynamic assessment of physiological processes, reduced inconsistency in spatial comparisons due to reduced motion artefacts and opens novel avenues for analysis. Initial results in pre-eclamptic placentas, with depicted changes in both ADC and T1, illustrate its potential to identify cases of placental insufficiency. Future work will focus on expanding the field-of-view using multi-band acceleration techniques and the expansion to larger and more diverse patient groups.
| Type: | Article |
|---|---|
| Title: | An efficient and combined placental T1-ADC acquisition in pregnancies with and without pre-eclampsia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.28809 |
| Publisher version: | https://doi.org/10.1002/mrm.28809 |
| Language: | English |
| Additional information: | © 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | ADC, diffusion, quantitative, relaxometry, T1, Placenta, pregnancy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10125519 |
Archive Staff Only
 |
View Item |
