Liu, Y;
Mohri, Z;
Alsheikh, W;
Cheema, U;
(2021)
The role of biomimetic hypoxia on cancer cell behaviour in 3d models: A systematic review.
Cancers
, 13
(6)
, Article 1334. 10.3390/cancers13061334.
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Abstract
The development of biomimetic, human tissue models is recognized as being an important step for transitioning in vitro research findings to the native in vivo response. Oftentimes, 2D models lack the necessary complexity to truly recapitulate cellular responses. The introduction of physiological features into 3D models informs us of how each component feature alters specific cellular response. We conducted a systematic review of research papers where the focus was the introduction of key biomimetic features into in vitro models of cancer, including 3D culture and hypoxia. We analysed outcomes from these and compiled our findings into distinct groupings to ascertain which biomimetic parameters correlated with specific responses. We found a number of biomimetic features which primed cancer cells to respond in a manner which matched in vivo response.
Type: | Article |
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Title: | The role of biomimetic hypoxia on cancer cell behaviour in 3d models: A systematic review |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.3390/cancers13061334 |
Publisher version: | https://doi.org/10.3390/cancers13061334 |
Language: | English |
Additional information: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | 3D; cancer models; hypoxia; cancer stem cells; drug resistance; epithelial-to-mesenchymal transition; invasion; migration |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science |
URI: | https://discovery.ucl.ac.uk/id/eprint/10125175 |
1. | United Kingdom | 12 |
2. | United States | 9 |
3. | China | 2 |
4. | Russian Federation | 2 |
5. | Turkey | 1 |
6. | Vietnam | 1 |
7. | Finland | 1 |
8. | Japan | 1 |
9. | Korea, Republic of | 1 |
10. | Norway | 1 |
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