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mRNA vaccines manufacturing: Challenges and bottlenecks

Rosa, SS; Prazeres, DMF; Azevedo, AM; Marques, MPC; (2021) mRNA vaccines manufacturing: Challenges and bottlenecks. Vaccine , 39 (16) pp. 2190-2200. 10.1016/j.vaccine.2021.03.038. Green open access

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Abstract

Vaccines are one of the most important tools in public health and play an important role in infectious diseases control. Owing to its precision, safe profile and flexible manufacturing, mRNA vaccines are reaching the stoplight as a new alternative to conventional vaccines. In fact, mRNA vaccines were the technology of choice for many companies to combat the Covid-19 pandemic, and it was the first technology to be approved in both United States and in Europe Union as a prophylactic treatment. Additionally, mRNA vaccines are being studied in the clinic to treat a number of diseases including cancer, HIV, influenza and even genetic disorders. The increased demand for mRNA vaccines requires a technology platform and cost-effective manufacturing process with a well-defined product characterisation. Large scale production of mRNA vaccines consists in a 1 or 2-step in vitro reaction followed by a purification platform with multiple steps that can include Dnase digestion, precipitation, chromatography or tangential flow filtration. In this review we describe the current state-of-art of mRNA vaccines, focusing on the challenges and bottlenecks of manufacturing that need to be addressed to turn this new vaccination technology into an effective, fast and cost-effective response to emerging health crises.

Type: Article
Title: mRNA vaccines manufacturing: Challenges and bottlenecks
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.vaccine.2021.03.038
Publisher version: https://dx.doi.org/10.1016/j.vaccine.2021.03.038
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Vaccination; mRNA vaccines; mRNA manufacturing; mRNA applications
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10124976
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