Merz, T;
Denoix, N;
Huber-Lang, M;
Singer, M;
Radermacher, P;
McCook, O;
(2020)
Microcirculation vs. Mitochondria-What to Target?
Frontiers in Medicine
, 7
, Article 416. 10.3389/fmed.2020.00416.
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Abstract
Circulatory shock is associated with marked disturbances of the macro- and microcirculation and flow heterogeneities. Furthermore, a lack of tissue adenosine trisphosphate (ATP) and mitochondrial dysfunction are directly associated with organ failure and poor patient outcome. While it remains unclear if microcirculation-targeted resuscitation strategies can even abolish shock-induced flow heterogeneity, mitochondrial dysfunction and subsequently diminished ATP production could still lead to organ dysfunction and failure even if microcirculatory function is restored or maintained. Preserved mitochondrial function is clearly associated with better patient outcome. This review elucidates the role of the microcirculation and mitochondria during circulatory shock and patient management and will give a viewpoint on the advantages and disadvantages of tailoring resuscitation to microvascular or mitochondrial targets.
| Type: | Article |
|---|---|
| Title: | Microcirculation vs. Mitochondria-What to Target? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fmed.2020.00416 |
| Publisher version: | https://doi.org/10.3389/fmed.2020.00416 |
| Language: | English |
| Additional information: | © 2020 Merz, Denoix, Huber-Lang, Singer, Radermacher and McCook. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Circulatory shock, oxidative stress, hypoxia, organ failure, inflammation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10124154 |
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