Picton, LD;
Bertuzzi, M;
Pallucchi, I;
Fontanel, P;
Dahlberg, E;
Björnfors, ER;
Iacoviello, F;
... El Manira, A; + view all
(2021)
A spinal organ of proprioception for integrated motor action feedback.
Neuron
10.1016/j.neuron.2021.01.018.
(In press).
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Abstract
Proprioception is essential for behavior and provides a sense of our body movements in physical space. Proprioceptor organs are thought to be only in the periphery. Whether the central nervous system can intrinsically sense its own movement remains unclear. Here we identify a segmental organ of proprioception in the adult zebrafish spinal cord, which is embedded by intraspinal mechanosensory neurons expressing Piezo2 channels. These cells are late-born, inhibitory, commissural neurons with unique molecular and physiological profiles reflecting a dual sensory and motor function. The central proprioceptive organ locally detects lateral body movements during locomotion and provides direct inhibitory feedback onto rhythm-generating interneurons responsible for the central motor program. This dynamically aligns central pattern generation with movement outcome for efficient locomotion. Our results demonstrate that a central proprioceptive organ monitors self-movement using hybrid neurons that merge sensory and motor entities into a unified network.
| Type: | Article |
|---|---|
| Title: | A spinal organ of proprioception for integrated motor action feedback |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2021.01.018 |
| Publisher version: | http://dx.doi.org/10.1016/j.neuron.2021.01.018 |
| Language: | English |
| Additional information: | © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Piezo2, locomotion, motor control, proprioception, spinal cord |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10123871 |
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