UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Linear brain atrophy measures in multiple sclerosis and clinically isolated syndromes: A 30-year follow-up

Haider, L; Chung, KK; Birch, G; Eshaghi, A; Mangesius, S; Prados Carrasco, F; Tur Gomez, C; ... Chard, DT; + view all (2021) Linear brain atrophy measures in multiple sclerosis and clinically isolated syndromes: A 30-year follow-up. Journal of Neurology, Neurosurgery & Psychiatry , 92 (8) pp. 839-846. 10.1136/jnnp-2020-325421. Green open access

[thumbnail of Haider_JNNP maintext correction 150121 clean v2-1.pdf]
Preview
Text
Haider_JNNP maintext correction 150121 clean v2-1.pdf - Accepted Version

Download (378kB) | Preview

Abstract

OBJECTIVE: To determine 30-year brain atrophy rates following clinically isolated syndromes and the relationship of atrophy in the first 5 years and clinical outcomes 25 years later. METHODS: A cohort of 132 people who presented with a clinically isolated syndrome suggestive of multiple sclerosis (MS) were recruited between 1984–1987. Clinical and MRI data were collected prospectively over 30 years. Widths of the third ventricle and the medulla oblongata were used as linear atrophy measures. RESULTS: At 30 years, 27 participants remained classified as having had a clinically isolated syndrome, 34 converted to relapsing remitting MS, 26 to secondary progressive MS and 16 had died due to MS. The mean age at baseline was 31.7 years (SD 7.5) and the mean disease duration was 30.8 years (SD 0.9). Change in medullary and third ventricular width within the first 5 years, allowing for white matter lesion accrual and Expanded Disability Status Scale increases over the same period, predicted clinical outcome measures at 30 years. 1 mm of medullary atrophy within the first 5 years increased the risk for secondary progressive MS or MS related death by 30 years by 583% (OR 5.83, 95% CI 1.74 to 19.61, p<0.005), using logistic regression. CONCLUSIONS: Our findings show that brain regional atrophy within 5 years of a clinically isolated syndrome predicts progressive MS or a related death, and disability 25 years later.

Type: Article
Title: Linear brain atrophy measures in multiple sclerosis and clinically isolated syndromes: A 30-year follow-up
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2020-325421
Publisher version: http://dx.doi.org/10.1136/jnnp-2020-325421
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10123742
Downloads since deposit
219Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item