Oettl, L-L;
Scheller, M;
Filosa, C;
Wieland, S;
Haag, F;
Loeb, C;
Durstewitz, D;
... Kelsch, W; + view all
(2020)
Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction.
Nature Communications
, 11
, Article 3460. 10.1038/s41467-020-17257-7.
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Abstract
The learning of stimulus-outcome associations allows for predictions about the environment. Ventral striatum and dopaminergic midbrain neurons form a larger network for generating reward prediction signals from sensory cues. Yet, the network plasticity mechanisms to generate predictive signals in these distributed circuits have not been entirely clarified. Also, direct evidence of the underlying interregional assembly formation and information transfer is still missing. Here we show that phasic dopamine is sufficient to reinforce the distinctness of stimulus representations in the ventral striatum even in the absence of reward. Upon such reinforcement, striatal stimulus encoding gives rise to interregional assemblies that drive dopaminergic neurons during stimulus-outcome learning. These assemblies dynamically encode the predicted reward value of conditioned stimuli. Together, our data reveal that ventral striatal and midbrain reward networks form a reinforcing loop to generate reward prediction coding.
| Type: | Article |
|---|---|
| Title: | Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-020-17257-7 |
| Publisher version: | https://doi.org/10.1038/s41467-020-17257-7 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, VENTRAL STRIATUM, NEURONS, REPRESENTATIONS, UNCERTAINTY, ACTIVATION, SIGNALS, MODELS, ROLES, PSYCHOSIS, BEHAVIOR |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10123650 |
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